Two sample MR report

Telomere_length against aparc-a2009s rh thickness Pole-occipital

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1889516	0.0994047	0.0711378
Weighted median	23	-0.0802478	0.0568632	0.1581727
Inverse variance weighted	23	-0.0636841	0.0388451	0.1011218
Simple mode	23	-0.1002912	0.1030976	0.3412379
Weighted mode	23	-0.1243800	0.0764833	0.1181391

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.96578	21	0.5873355
Inverse variance weighted	20.84003	22	0.5306424

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0076915	0.0056182	0.1854547

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000713	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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