Two sample MR report

Telomere_length against aparc-a2009s rh thickness Lat-Fis-post

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0712501	0.1169215	0.5488071
Weighted median	23	-0.0214952	0.0549388	0.6956078
Inverse variance weighted	23	-0.0102963	0.0449788	0.8189362
Simple mode	23	-0.0133795	0.0944082	0.8885910
Weighted mode	23	-0.0277311	0.0597130	0.6469192

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.05213	21	0.1127555
Inverse variance weighted	29.49588	22	0.1312405

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0037425	0.0066081	0.5771558

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008959	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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