Two sample MR report

Telomere_length against aparc-a2009s rh thickness Lat-Fis-ant-Vertical

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0639945	0.1273262	0.6204740
Weighted median	23	0.0788836	0.0621945	0.2046777
Inverse variance weighted	23	0.0599711	0.0498917	0.2293534
Simple mode	23	0.0216706	0.1219633	0.8605989
Weighted mode	23	-0.0181043	0.0879556	0.8388129

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.44113	21	0.0324862
Inverse variance weighted	36.27596	22	0.0283609

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0076117	0.0071964	0.3022015

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011714	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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