Two sample MR report

Telomere_length against aparc-a2009s rh thickness Lat-Fis-ant-Horizont

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0211475	0.0994090	0.8335868
Weighted median	23	-0.0341371	0.0540123	0.5273708
Inverse variance weighted	23	-0.0282633	0.0388467	0.4668829
Simple mode	23	-0.1087339	0.0963821	0.2714081
Weighted mode	23	-0.0493776	0.0698314	0.4869284

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.30577	21	0.8073024
Inverse variance weighted	15.59735	22	0.8353545

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030339	0.0056184	0.5948896

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004887	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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