Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-temp-sup-Plan-tempo

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2391483	0.1010298	0.0276109
Weighted median	23	-0.0529497	0.0579624	0.3609701
Inverse variance weighted	23	-0.0347132	0.0427811	0.4171278
Simple mode	23	-0.0342250	0.1129732	0.7647755
Weighted mode	23	-0.1342793	0.0826171	0.1183354

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.69283	21	0.4173919
Inverse variance weighted	26.68485	22	0.2234414

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0125524	0.00571	0.0392762

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008328	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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