Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-temp-sup-Plan-polar

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0151837	0.0994064	0.8800587
Weighted median	23	-0.0313940	0.0582597	0.5899806
Inverse variance weighted	23	-0.0276689	0.0388454	0.4762904
Simple mode	23	-0.0664611	0.1017047	0.5202246
Weighted mode	23	-0.0174214	0.0658106	0.7936895

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.75659	21	0.5367225
Inverse variance weighted	19.77521	22	0.5970986

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007666	0.0056182	0.8927677

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006146	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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