Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-temp-sup-G-T-transv

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0549803	0.1052746	0.6069575
Weighted median	23	0.0010656	0.0570711	0.9851033
Inverse variance weighted	23	-0.0128134	0.0403737	0.7509634
Simple mode	23	0.0623036	0.0973347	0.5287202
Weighted mode	23	0.0264334	0.0714742	0.7150451

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.55202	21	0.3152667
Inverse variance weighted	23.76438	22	0.3597006

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002589	0.0059499	0.6678981

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007234	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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