Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-temporal-middle

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1215231	0.1240068	0.3382559
Weighted median	23	0.0943094	0.0580888	0.1044745
Inverse variance weighted	23	0.0464398	0.0497254	0.3503427
Simple mode	23	0.2075875	0.0980564	0.0458004
Weighted mode	23	0.1367973	0.0920300	0.1513536

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.68080	21	0.0498786
Inverse variance weighted	36.05037	22	0.0299910

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0103129	0.0070086	0.1559927

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011356	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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