Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-temporal-inf

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0904354	0.1211757	0.4637501
Weighted median	23	0.0108155	0.0627892	0.8632399
Inverse variance weighted	23	-0.0405394	0.0464839	0.3831441
Simple mode	23	-0.0557281	0.1143975	0.6309743
Weighted mode	23	0.0175231	0.1042407	0.8680382

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.20653	21	0.0702888
Inverse variance weighted	31.50389	22	0.0862563

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030636	0.0068486	0.659213

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009875	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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