Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-subcallosal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0356646	0.0994047	0.7233405
Weighted median	23	0.1246926	0.0612865	0.0418924
Inverse variance weighted	23	0.0668890	0.0388450	0.0850790
Simple mode	23	0.1463924	0.1033583	0.1706749
Weighted mode	23	0.1514616	0.1064980	0.1689921

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.41932	21	0.4948577
Inverse variance weighted	21.67550	22	0.4793939

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0062968	0.0056182	0.2750287

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007467	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8