Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-rectus

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0653388	0.1168014	0.5818061
Weighted median	23	0.0064371	0.0605247	0.9153005
Inverse variance weighted	23	0.0099415	0.0448746	0.8246723
Simple mode	23	0.0132268	0.1204705	0.9135687
Weighted mode	23	0.0405170	0.0990961	0.6865909

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.99324	21	0.1141639
Inverse variance weighted	29.35978	22	0.1348727

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034014	0.0066014	0.6117558

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008916	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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