Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-precuneus

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1278292	0.1186961	0.2937215
Weighted median	23	-0.0476850	0.0573791	0.4059442
Inverse variance weighted	23	-0.0752719	0.0455662	0.0985496
Simple mode	23	0.0256127	0.0895288	0.7774911
Weighted mode	23	-0.0658829	0.0633000	0.3092700

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.94180	21	0.0931639
Inverse variance weighted	30.27172	22	0.1120083

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.003227	0.0067084	0.6354636

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001031	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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