Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-precentral

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1904082	0.1351383	0.1734748
Weighted median	23	-0.0058523	0.0573632	0.9187399
Inverse variance weighted	23	-0.0132805	0.0540280	0.8058312
Simple mode	23	0.0837103	0.1091443	0.4512530
Weighted mode	23	-0.0247964	0.0712293	0.7310584

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.81231	21	0.0103343
Inverse variance weighted	42.55972	22	0.0053439

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0108756	0.0076377	0.1691547

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012931	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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