Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-postcentral

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2307569	0.0994045	0.0304064
Weighted median	23	-0.0968724	0.0521236	0.0630962
Inverse variance weighted	23	-0.0675818	0.0388449	0.0818967
Simple mode	23	-0.0890253	0.1026891	0.3953322
Weighted mode	23	-0.1304069	0.0674586	0.0661912

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.11950	21	0.8644116
Inverse variance weighted	17.29976	22	0.7466052

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.010019	0.0056182	0.0889944

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006159	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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