Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-pariet-inf-Supramar

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1237023	0.0994059	0.2270567
Weighted median	23	-0.0604017	0.0530856	0.2551968
Inverse variance weighted	23	-0.0571828	0.0388454	0.1410041
Simple mode	23	-0.0818844	0.0977923	0.4114118
Weighted mode	23	-0.1086694	0.0693280	0.1312776

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	9.632672	21	0.9832984
Inverse variance weighted	10.161164	22	0.9847837

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0040843	0.0056182	0.4752679

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003736	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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