Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-pariet-inf-Angular

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0313066	0.0994070	0.7559197
Weighted median	23	-0.0071502	0.0550051	0.8965736
Inverse variance weighted	23	-0.0007253	0.0388456	0.9851038
Simple mode	23	-0.0265615	0.0857024	0.7595332
Weighted mode	23	-0.0028313	0.0647638	0.9655246

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.14071	21	0.5761143
Inverse variance weighted	19.26325	22	0.6290211

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019667	0.0056182	0.7297768

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005837	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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