Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-parietal-sup

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1200671	0.1090611	0.2833926
Weighted median	23	-0.0237494	0.0567908	0.6758082
Inverse variance weighted	23	-0.0432666	0.0422148	0.3054028
Simple mode	23	0.0201263	0.0930658	0.8307785
Weighted mode	23	-0.0194246	0.0660937	0.7715933

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.27777	21	0.2353342
Inverse variance weighted	25.98226	22	0.2524446

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0047156	0.0061639	0.4527675

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008249	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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