Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-orbital

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0022888	0.0994064	0.9818477
Weighted median	23	0.0014482	0.0556140	0.9792247
Inverse variance weighted	23	-0.0301225	0.0388455	0.4380773
Simple mode	23	0.0017681	0.0932018	0.9850356
Weighted mode	23	-0.0041541	0.0652863	0.9498397

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.10502	21	0.6423488
Inverse variance weighted	18.23049	22	0.6922385

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019901	0.0056182	0.7267106

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005707	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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