Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-oc-temp-med-Parahip

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1089079	0.1001447	0.2891382
Weighted median	23	-0.0566430	0.0587364	0.3348651
Inverse variance weighted	23	0.0019372	0.0395287	0.9609132
Simple mode	23	-0.0667424	0.1035943	0.5260631
Weighted mode	23	-0.0535484	0.0685796	0.4432293

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.31333	21	0.4399575
Inverse variance weighted	22.78081	22	0.4141935

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0068059	0.0056599	0.2425681

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006904	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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