Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-oc-temp-med-Lingual

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1882592	0.1056527	0.0892385
Weighted median	23	0.0179515	0.0561872	0.7493520
Inverse variance weighted	23	0.0270906	0.0447996	0.5453742
Simple mode	23	-0.0357762	0.0998379	0.7235026
Weighted mode	23	-0.0135077	0.0650782	0.8374811

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.72229	21	0.3067079
Inverse variance weighted	29.26128	22	0.1375512

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0132224	0.0059712	0.0379998

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009014	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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