Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-oc-temp-lat-fusifor

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1712168	0.1129662	0.1445174
Weighted median	23	-0.0248274	0.0568520	0.6623269
Inverse variance weighted	23	-0.0581271	0.0443275	0.1897528
Simple mode	23	0.0245740	0.0954919	0.7993068
Weighted mode	23	-0.0067391	0.0701495	0.9243368

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.12090	21	0.1668871
Inverse variance weighted	28.64847	22	0.1551735

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0069437	0.0063846	0.2891102

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009359	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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