Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-occipital-sup

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1294365	0.1122094	0.2616549
Weighted median	23	0.0010192	0.0594770	0.9863279
Inverse variance weighted	23	-0.0120536	0.0441385	0.7847880
Simple mode	23	0.0050082	0.0974203	0.9594643
Weighted mode	23	0.0013210	0.0806952	0.9870864

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.75889	21	0.1789771
Inverse variance weighted	28.40465	22	0.1626554

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0072073	0.0063418	0.268562

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008636	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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