Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-occipital-middle

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0173518	0.1209620	0.8873036
Weighted median	23	-0.0348513	0.0561515	0.5348199
Inverse variance weighted	23	-0.0269165	0.0463555	0.5614738
Simple mode	23	-0.0167335	0.0864008	0.8482090
Weighted mode	23	-0.0504117	0.0625157	0.4286518

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.09515	21	0.0720889
Inverse variance weighted	31.32921	22	0.0895732

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002718	0.0068365	0.694951

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009638	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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