Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-insular-short

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0001087	0.1344329	0.9993627
Weighted median	23	-0.0091576	0.0549644	0.8676768
Inverse variance weighted	23	-0.0004568	0.0513250	0.9928991
Simple mode	23	0.0229013	0.0968910	0.8153392
Weighted mode	23	0.0189609	0.0628368	0.7656781

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.40665	21	0.0115444
Inverse variance weighted	38.40667	22	0.0164872

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-2.14e-05	0.0075978	0.9977819

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011637	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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