Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-front-sup

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1604433	0.1066500	0.1473729
Weighted median	23	-0.0018364	0.0593556	0.9753179
Inverse variance weighted	23	-0.0279401	0.0424477	0.5103942
Simple mode	23	0.0630745	0.1065614	0.5599467
Weighted mode	23	0.0230583	0.0831116	0.7840342

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.17300	21	0.2847520
Inverse variance weighted	26.27005	22	0.2402682

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0081357	0.0060277	0.1914718

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008117	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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