Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-front-middle

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1080601	0.1322633	0.4230968
Weighted median	23	-0.0272905	0.0562419	0.6275105
Inverse variance weighted	23	-0.0081119	0.0513007	0.8743583
Simple mode	23	0.0126244	0.0925655	0.8927585
Weighted mode	23	-0.0367531	0.0615304	0.5563950

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.17744	21	0.0160614
Inverse variance weighted	38.37059	22	0.0166428

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0061368	0.0074752	0.4208958

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001164	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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