Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-front-inf-Triangul

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0150827	0.0994079	0.8808518
Weighted median	23	0.0054148	0.0532333	0.9189809
Inverse variance weighted	23	-0.0080301	0.0388462	0.8362328
Simple mode	23	-0.0056677	0.0907488	0.9507647
Weighted mode	23	-0.0056677	0.0678072	0.9341420

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.17517	21	0.8140608
Inverse variance weighted	15.18111	22	0.8543491

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000433	0.0056183	0.9392937

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004613	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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