Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-front-inf-Orbital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0370208	0.0994083	0.7133187
Weighted median	23	-0.0137380	0.0547227	0.8017768
Inverse variance weighted	23	-0.0796180	0.0388465	0.0404077
Simple mode	23	0.0003950	0.0909583	0.9965743
Weighted mode	23	0.0003950	0.0694913	0.9955161

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.30187	21	0.6298292
Inverse variance weighted	18.51858	22	0.6748372

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0026155	0.0056184	0.6463483

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006885	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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