Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-front-inf-Opercular

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0557938	0.1093222	0.6151213
Weighted median	23	-0.0000574	0.0556672	0.9991767
Inverse variance weighted	23	0.0179102	0.0418787	0.6688920
Simple mode	23	-0.0230963	0.0883359	0.7961699
Weighted mode	23	0.0093854	0.0600792	0.8772863

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.39835	21	0.2303238
Inverse variance weighted	25.56976	22	0.2706119

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002326	0.0061786	0.7103477

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007813	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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