Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1131547	0.1216477	0.3628461
Weighted median	23	-0.0059950	0.0600142	0.9204298
Inverse variance weighted	23	0.0024840	0.0476086	0.9583887
Simple mode	23	-0.1180564	0.1071930	0.2826508
Weighted mode	23	-0.0370309	0.0649777	0.5745190

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.44882	21	0.0665059
Inverse variance weighted	33.04599	22	0.0612299

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0071001	0.0068752	0.3134829

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010015	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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