Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-cingul-Post-ventral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0192303	0.1317473	0.8853423
Weighted median	23	0.0326136	0.0556321	0.5577162
Inverse variance weighted	23	0.0121705	0.0503799	0.8091096
Simple mode	23	0.0436026	0.1070438	0.6876990
Weighted mode	23	0.0349907	0.0595238	0.5626231

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.88721	21	0.0173429
Inverse variance weighted	37.00498	22	0.0236261

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001928	0.007446	0.7982108

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011242	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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