Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-cingul-Post-dorsal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0843660	0.0994066	0.4056214
Weighted median	23	-0.0069050	0.0533468	0.8970131
Inverse variance weighted	23	-0.0169429	0.0388456	0.6627211
Simple mode	23	0.0770360	0.0941297	0.4219043
Weighted mode	23	0.0083938	0.0617207	0.8930607

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.08475	21	0.7648705
Inverse variance weighted	16.62769	22	0.7835611

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041398	0.0056182	0.4693693

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005096	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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