Two sample MR report

Telomere_length against aparc-a2009s rh thickness G+S-transv-frontopol

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1537627	0.1176824	0.2054810
Weighted median	23	0.0278195	0.0594117	0.6396062
Inverse variance weighted	23	-0.0185040	0.0465685	0.6911100
Simple mode	23	0.1135976	0.1221131	0.3623298
Weighted mode	23	0.0679622	0.0997690	0.5028553

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.43373	21	0.1039718
Inverse variance weighted	31.61898	22	0.0841281

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.008305	0.0066512	0.225538

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000965	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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