Two sample MR report

Telomere_length against aparc-a2009s rh thickness G+S-subcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0982761	0.1019924	0.3462306
Weighted median	23	-0.0106574	0.0568257	0.8512329
Inverse variance weighted	23	-0.0061165	0.0398232	0.8779310
Simple mode	23	-0.0372227	0.0930511	0.6929962
Weighted mode	23	-0.0204707	0.0643939	0.7535601

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.10710	21	0.3933605
Inverse variance weighted	23.12154	22	0.3948942

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056586	0.0057644	0.3374488

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007014	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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