Two sample MR report

Telomere_length against aparc-a2009s rh thickness G+S-paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2404666	0.1136043	0.0463951
Weighted median	23	-0.0141029	0.0580289	0.8079797
Inverse variance weighted	23	-0.0284304	0.0474297	0.5488918
Simple mode	23	-0.0158131	0.0948429	0.8691058
Weighted mode	23	-0.0069656	0.0744630	0.9263176

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.42875	21	0.1571083
Inverse variance weighted	32.79886	22	0.0647597

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.013019	0.0064206	0.0554712

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010101	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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