Two sample MR report

Telomere_length against aparc-a2009s rh thickness G+S-occipital-inf

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0517660 0.1042947 0.6248072
Weighted median 23 -0.0474451 0.0536319 0.3763488
Inverse variance weighted 23 -0.0269972 0.0398816 0.4984484
Simple mode 23 -0.0109257 0.0852015 0.8991293
Weighted mode 23 -0.0409939 0.0579814 0.4869771

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.11617 21 0.3378159
Inverse variance weighted 23.18944 22 0.3910993

Test for directional horizontal pleiotropy

egger_intercept se pval
0.0015208 0.0058945 0.7989153

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007173 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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