Two sample MR report

Telomere_length against aparc-a2009s rh thickness G+S-frontomargin

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1047287	0.1270009	0.4188505
Weighted median	23	0.0496968	0.0628106	0.4288178
Inverse variance weighted	23	0.0240409	0.0498688	0.6297473
Simple mode	23	0.1112552	0.1187665	0.3590545
Weighted mode	23	0.0740652	0.0923024	0.4308944

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.27726	21	0.0338376
Inverse variance weighted	36.25772	22	0.0284897

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0079065	0.0071779	0.2831395

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011102	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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