Two sample MR report

Telomere_length against aparc-a2009s rh thickness G+S-cingul-Mid-Post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0655476	0.0994064	0.5168116
Weighted median	23	0.0682073	0.0552795	0.2172538
Inverse variance weighted	23	0.0707988	0.0388456	0.0683687
Simple mode	23	0.1044934	0.0716199	0.1586966
Weighted mode	23	0.0702398	0.0585029	0.2426667

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.98800	21	0.8701143
Inverse variance weighted	16.20836	22	0.8054118

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0083716	0.0056182	0.1510683

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005918	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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