Two sample MR report

Telomere_length against aparc-a2009s rh thickness G+S-cingul-Mid-Ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1080994	0.0994062	0.2891617
Weighted median	23	0.0451168	0.0590450	0.4448021
Inverse variance weighted	23	0.0559131	0.0388453	0.1500436
Simple mode	23	0.1038914	0.1094371	0.3527683
Weighted mode	23	-0.0220092	0.0719460	0.7625469

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.59261	21	0.7354859
Inverse variance weighted	19.80547	22	0.5952065

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0100703	0.0056182	0.0874814

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006629	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8