Two sample MR report

Telomere_length against aparc-a2009s rh thickness G+S-cingul-Ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1534384	0.0994052	0.1376301
Weighted median	23	-0.0473106	0.0567705	0.4046379
Inverse variance weighted	23	-0.0174795	0.0388453	0.6527272
Simple mode	23	-0.0948736	0.0948204	0.3279177
Weighted mode	23	-0.0872785	0.0703374	0.2277291

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.01941	21	0.5838951
Inverse variance weighted	21.22723	22	0.5067356

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0083479	0.0056182	0.1521718

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006494	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8