Two sample MR report

Telomere_length against aparc-a2009s rh thickness G-Ins-lg+S-cent-ins

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1476490	0.1201572	0.2327402
Weighted median	23	-0.0495496	0.0556597	0.3733452
Inverse variance weighted	23	-0.0508121	0.0467045	0.2766180
Simple mode	23	-0.1263901	0.0994801	0.2171764
Weighted mode	23	-0.0654975	0.0630041	0.3098282

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.68282	21	0.0791012
Inverse variance weighted	31.80283	22	0.0808203

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0059457	0.006791	0.3911877

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010156	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8