Two sample MR report

Telomere_length against aparc-a2009s rh area S-temporal-transverse

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3019115	0.1133445	0.0145324
Weighted median	23	-0.0634204	0.0638078	0.3202583
Inverse variance weighted	23	-0.0211934	0.0501817	0.6727823
Simple mode	23	0.0541293	0.1195816	0.6552289
Weighted mode	23	-0.0795425	0.0693701	0.2638489

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.30143	21	0.1610971
Inverse variance weighted	36.71322	22	0.0254274

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0172361	0.006406	0.0136914

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011215	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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