Two sample MR report

Telomere_length against aparc-a2009s rh area S-temporal-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0395871	0.1324347	0.7679405
Weighted median	23	-0.0793303	0.0580237	0.1715607
Inverse variance weighted	23	-0.0855583	0.0507329	0.0917098
Simple mode	23	-0.0655193	0.1116082	0.5631486
Weighted mode	23	-0.0825621	0.0644196	0.2133159

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.27372	21	0.0156559
Inverse variance weighted	37.52613	22	0.0206948

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0028226	0.0074849	0.7098776

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001284	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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