Two sample MR report

Telomere_length against aparc-a2009s rh area S-temporal-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1018621	0.0994036	0.3171490
Weighted median	23	0.0277617	0.0586861	0.6361751
Inverse variance weighted	23	-0.0153831	0.0388449	0.6920946
Simple mode	23	0.1027401	0.1004111	0.3173357
Weighted mode	23	0.0782335	0.0922993	0.4057843

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.09533	21	0.5790249
Inverse variance weighted	19.98860	22	0.5837527

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0053099	0.0056182	0.35534

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006104	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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