Two sample MR report

Telomere_length against aparc-a2009s rh area S-subparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1966622	0.1195893	0.1149649
Weighted median	23	-0.0389199	0.0554166	0.4824828
Inverse variance weighted	23	-0.0159415	0.0484995	0.7423863
Simple mode	23	-0.0883006	0.0792378	0.2771451
Weighted mode	23	-0.0462810	0.0582045	0.4350249

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.39335	21	0.0843640
Inverse variance weighted	34.29417	22	0.0458422

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0110961	0.0067588	0.115541

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010442	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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