Two sample MR report

Telomere_length against aparc-a2009s rh area S-precentral-sup-part

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0726264	0.1005877	0.4782453
Weighted median	23	0.0058610	0.0542227	0.9139236
Inverse variance weighted	23	-0.0097275	0.0391200	0.8036250
Simple mode	23	0.0481429	0.0959225	0.6207287
Weighted mode	23	0.0273156	0.0608239	0.6577572

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.50191	21	0.4286823
Inverse variance weighted	22.31194	22	0.4414070

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0050565	0.005685	0.3838369

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000678	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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