Two sample MR report

Telomere_length against aparc-a2009s rh area S-precentral-inf-part

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1260579	0.0994059	0.2186370
Weighted median	23	-0.1087762	0.0572814	0.0575671
Inverse variance weighted	23	-0.0705808	0.0388452	0.0692211
Simple mode	23	-0.1349788	0.0917031	0.1552065
Weighted mode	23	-0.1248611	0.0739183	0.1053100

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.90500	21	0.8736452
Inverse variance weighted	14.27259	22	0.8915226

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034063	0.0056182	0.5508168

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005325	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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