Two sample MR report

Telomere_length against aparc-a2009s rh area S-postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0323683	0.1152437	0.7815602
Weighted median	23	-0.0240748	0.0607681	0.6919764
Inverse variance weighted	23	-0.0150456	0.0442076	0.7336017
Simple mode	23	-0.1247477	0.1055807	0.2500040
Weighted mode	23	-0.0509671	0.0719280	0.4860233

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.22458	21	0.1338962
Inverse variance weighted	28.49308	22	0.1599103

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029112	0.0065133	0.6594784

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000868	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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