Two sample MR report

Telomere_length against aparc-a2009s rh area S-pericallosal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0208004	0.1360404	0.8799376
Weighted median	23	-0.0143593	0.0551729	0.7946634
Inverse variance weighted	23	-0.0068300	0.0519537	0.8954088
Simple mode	23	-0.1265396	0.0916942	0.1814452
Weighted mode	23	-0.0273441	0.0598069	0.6520052

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.32973	21	0.0089620
Inverse variance weighted	39.35304	22	0.0128529

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008578	0.0076887	0.9122286

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011933	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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