Two sample MR report

Telomere_length against aparc-a2009s rh area S-parieto-occipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1482338	0.0994048	0.1507747
Weighted median	23	-0.0921048	0.0579733	0.1121178
Inverse variance weighted	23	-0.0728195	0.0388449	0.0608448
Simple mode	23	-0.0837658	0.1089087	0.4499907
Weighted mode	23	-0.0811140	0.0875056	0.3640068

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.24512	21	0.5057863
Inverse variance weighted	20.92441	22	0.5254138

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0046305	0.0056182	0.4190926

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007405	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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